Cleveland Heart Failure Summit 2026
Advanced Heart Failure, Cardiomyopathy, Amyloidosis, Cardiogenic Shock,
Mechanical Support, AI and Precision Medicine
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The Cleveland Heart Failure Summit 2026 is a comprehensive, expert-led educational
program focused on the latest advances in heart failure, cardiomyopathy and complex cardiovascular care.
Featuring 41 specialist-led video sessions, the program brings together leading clinicians
from the Cleveland Clinic Heart, Vascular and Thoracic Institute to examine emerging evidence, evolving
clinical guidelines and practical strategies for managing patients across the full spectrum of heart failure.
The course covers contemporary management of HFrEF and HFpEF, cardiac amyloidosis,
inflammatory and genetic cardiomyopathies, cardio-kidney-metabolic disease, cardiogenic shock,
mechanical circulatory support, ECMO, LVAD therapy, heart transplantation, structural heart disease
and arrhythmias.
Participants will also explore rapidly developing areas such as artificial intelligence,
gene therapy, regenerative medicine, remote pulmonary artery monitoring and precision medicine.
❤️ Course Overview
Heart failure management is rapidly changing with the introduction of new medications, devices,
imaging techniques, metabolic therapies and advanced mechanical support strategies.
This program provides practical and evidence-based guidance on:
- Optimizing guideline-directed medical therapy
- Managing HFrEF and HFpEF across different clinical phenotypes
- Interpreting major recent heart failure trials
- Diagnosing and treating cardiac amyloidosis
- Recognizing advanced and end-stage heart failure
- Selecting temporary and durable mechanical circulatory support
- Managing cardiogenic shock
- Applying CKM and population-health care models
- Evaluating patients for LVAD and heart transplantation
- Incorporating AI, genetics and precision medicine into clinical care
Dedicated expert discussions and case-based presentations help connect emerging evidence with
real-world clinical decision-making.
⭐ Key Course Highlights
Heart Failure Therapeutics
Explore the evolving role of guideline-directed therapy, digitalis, vericiguat, metabolic interventions
and emerging pharmacologic approaches for HFrEF and HFpEF.
Cardiac Amyloidosis
Review nuclear imaging, transthyretin therapies, gene-editing strategies, AL amyloidosis,
musculoskeletal manifestations and patient education following a new diagnosis.
Cardiogenic Shock and Advanced Support
Learn practical approaches to cardiogenic shock, temporary mechanical circulatory support,
ECMO cannulation, LVAD management and advanced heart failure referral.
Cardiomyopathy and Precision Medicine
Examine genetic cardiomyopathies, CD36 variants, cardiac sarcoidosis, cardio-oncology
and regenerative and gene-based therapies.
Artificial Intelligence and Digital Health
Understand how AI can support risk prediction, clinical decision-making, workflow integration
and personalized heart failure management.
Cardio-Kidney-Metabolic Care
Review CKM care models, obesity treatment, exercise, nutrition, population-health strategies
and equitable access to advanced therapies.
Structural Heart Disease and Arrhythmias
Explore TAVR in patients with aortic stenosis and HFrEF, surgical decision-making and
catheter ablation for atrial fibrillation in heart failure.
🎯 Learning Objectives
After completing this course, learners should be able to:
-
Apply precision medicine principles to the evaluation and management of patients
with heart failure across the ejection-fraction spectrum using genetic, imaging, metabolic and
phenotypic information. -
Integrate contemporary evidence in guideline-directed medical therapy, devices,
advanced therapies and obesity-related treatments into daily clinical care for HFrEF and HFpEF. - Interpret major clinical trials and apply their findings to individualized patient management.
-
Recognize advanced heart failure earlier and identify patients who may benefit from
mechanical circulatory support, LVAD therapy or transplant evaluation. -
Select appropriate critical-care therapies, including temporary mechanical circulatory
support and different ECMO configurations. - Improve diagnosis and treatment of cardiac amyloidosis, including TTR and AL amyloidosis.
-
Implement CKM and population-health models to improve coordinated, equitable and
scalable heart failure care. -
Use emerging technologies such as artificial intelligence, remote monitoring,
gene therapy, regenerative medicine and advanced imaging to improve detection and risk stratification. -
Manage complex clinical intersections involving arrhythmias, structural heart disease,
oncology, metabolic disease and inflammatory cardiomyopathies.
👨⚕️ Who Should Attend?
This course is suitable for healthcare professionals involved in the diagnosis or management of heart failure, including:
Heart failure specialists
Internal medicine physicians
Critical care physicians
Cardiac surgeons
Electrophysiologists
Advanced heart failure and transplant teams
Physician assistants
Nurse practitioners
Nurses
Pharmacists
Cardiology fellows and trainees
Other healthcare professionals interested in cardiovascular medicine
📚 Topics and Videos Covered
The program includes 41 expert-led sessions covering:
HFrEF and HFpEF
Guideline-directed medical therapy
Cardiac amyloidosis
Transthyretin and AL amyloidosis
Nuclear cardiac imaging
Gene editing and gene therapy
Cardiogenic shock
ECMO cannulation strategies
Temporary mechanical circulatory support
LVAD care
Heart transplantation and allocation
Cardiac sarcoidosis
Genetic cardiomyopathies
Cardio-oncology
Structural heart disease and TAVR
Atrial fibrillation and catheter ablation
Artificial intelligence in heart failure
Remote pulmonary artery monitoring
CKM syndrome
Obesity and metabolic disease
Nutrition and exercise in HFpEF
Population-health strategies
Equitable access to advanced heart failure care
Practice-changing cardiovascular trials
Regenerative therapies and future innovations
🎬 Selected Sessions
- Cardiac Amyloidosis: Expert Q&A on Diagnosis and Management
- ECMO Cannulation Strategy: Choosing VA, VAV, LAVA and Other Configurations
- Cardiogenic Shock: From Guidelines to Bedside
- Temporary MCS Devices: Right Device, Right Patient, Right Time
- Personalizing Care for LVAD Recipients
- Heart Allocation by Continuous Distribution
- HFpEF and Obesity: Findings From the SUMMIT Trial
- HFpEF: Insights From FINEARTS-HF and RE-DEFINE-HF
- Vericiguat for HFrEF: Results From the VICTOR Trial
- The Role of Digitalis in HFrEF Therapeutics
- AI in HF: From Risk Prediction to Workflow Integration
- Gene Therapy for Cardiomyopathies
- CKM Care Models: Practical Implementation
- Cardiac Sarcoidosis Across the EF Spectrum
- Cardio-Oncology in the Advanced HF Clinic
- Atrial Fibrillation in Heart Failure
- TAVR in Patients With Aortic Stenosis and HFrEF
📅 Original Event Information
Cleveland Heart Failure Summit
Dates: June 12–13, 2026
Location: InterContinental Hotel & Conference Center, Cleveland, Ohio













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